Maternal-fetal health
Maternal-fetal health is an area of research that has often been overlooked. Many times the problems pregnant women face can be hard to study due to lack of knowledge of an intricate process. The connection between the maternal and fetal systems and the development baby are continually changing and make-up a complex system. The health of the mother during pregnancy not only has consequences on her but also the developing baby. Our lab studies many different facets of the maternal-fetal health space. From understanding placental development, to developing therapeutics to treat pregnant women without harming the developing baby, to understanding lung development in premature babies. In order to study these areas we have developed many tools and platforms to probe information.
SI Hofbauer, LA Fink, RE Young, T Vijayakumar, KM Nelson, N Bellopede, M Alameh, D Weissman, JP Gleghorn, RS Riley (2025) Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles, BioRxiv, doi: 2025.02.07.637086
KM Nelson, BJ Ferrick, H Karimi, CL Hatem, and JP Gleghorn (2024) A straightforward cell culture insert model to incorporate biochemical and biophysical stromal properties into transplacental transport studies. Placenta. 2024 Sep 5
RE Young, KM Nelson, SI Hofbauer, T Vijayakumar, MG Alameh, D Weissman, C Papachristou, JP Gleghorn, RS Riley. (2024) Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach. Bioactive Materials, 34, 125-137
NS Irvin-Choy*, KM Nelson*, JP Gleghorn**, ES Day**. (2023) Delivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles, Drug Deliv. and Transl. Res.,13(12), 3003-3013 *demotes equal contribution. **denotes co-corresponding authorship.
VL Edwards, E McComb, JP Gleghorn, L Forney, PM Bavoil, J Ravel. (2022) Three-dimensional models of the cervicovaginal epithelia to study host-microbiome interactions and sexually transmitted infections. Pathogens and Disease, 80(1): ftac026.
KM Nelson, N Irvin-Choy, MK Hoffman, JP Gleghorn*, ES Day*. (2021) Diseases and conditions that impact maternal and fetal health and the potential for nanomedicine therapies. Advanced Drug Delivery Reviews, 170:425-438. *denotes co-corresponding authors
NS Irvin-Choy*, KM Nelson*, MN Dang, JP Gleghorn**, ES Day**. (2021) Gold nanoparticle biodistribution in pregnant mice following intravenous administration varies with gestational age. Nanomedicine, 2021 Jun 17. *denotes co-first authors **denotes co-corresponding authors
N Irvin-Choy, KM Nelson, JP Gleghorn*, ES Day*. (2020) Design of nanomaterials for applications in maternal/fetal medicine. Journal of Materials Chemistry B, 8:6548-6561. *denotes co-corresponding authors