Drug Delivery
Effective therapeutic design requires optimizing potency, toxicity, availability, and dosage schemes for treatment. Delivery of effective therapies that are able to transport across restrictive endothelial barriers (e.g. blood-brain barrier and HEV-lymph node barrier) remains a central challenge to the treatment of several diseases and cancers. Additionally, gaining access to the lymph node paracortex can unlock improved vaccines and new therapies for autoimmune disorders. We are working on drug delivery strategies for enhanced therapeutic delivery to the lymph node and brain. These projects are in tight collaboration with the Zurakowski and Kwee Laboratories.
SI Hofbauer, LA Fink, RE Young, T Vijayakumar, KM Nelson, N Bellopede, M Alameh, D Weissman, JP Gleghorn, RS Riley (2025) Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles, BioRxiv, doi: 2025.02.07.637086
RE Young, KM Nelson, SI Hofbauer, T Vijayakumar, MG Alameh, D Weissman, C Papachristou, JP Gleghorn, RS Riley. (2024) Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach. Bioactive Materials, 34, 125-137
NS Irvin-Choy*, KM Nelson*, JP Gleghorn**, ES Day**. (2023) Delivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles, Drug Deliv. and Transl. Res.,13(12), 3003-3013 *denotes equal contribution. **denotes co-corresponding authorship.
KM Nelson, N Irvin-Choy, MK Hoffman, JP Gleghorn*, ES Day*. (2021) Diseases and conditions that impact maternal and fetal health and the potential for nanomedicine therapies. Advanced Drug Delivery Reviews, 170:425-438. PMID: 33002575 *denotes co-corresponding authors
NS Irvin-Choy*, KM Nelson*, MN Dang, JP Gleghorn**, ES Day**. (2021) Gold nanoparticle biodistribution in pregnant mice following intravenous administration varies with gestational age. Nanomedicine, Epub 2021 Jun 17. *denotes co-first authors **denotes co-corresponding authors
N Irvin-Choy, KM Nelson, JP Gleghorn*, ES Day*. (2020) Design of nanomaterials for applications in maternal/fetal medicine. Journal of Materials Chemistry B, 8:6548-6561. *denotes co-corresponding authors